Prey (2017) is an immersive sim set aboard Talos I, a space station orbiting the Moon that's been overrun by shape-shifting alien organisms called Typhon. As Morgan Yu, you choose between human abilities and alien Typhon powers via Neuromods, fundamentally changing how you approach every encounter and puzzle. The entire station is an interconnected open world you can explore in any order, with multiple solutions to every obstacle. The GLOO Cannon alone enables dozens of creative approaches by creating platforms, blocking hazards, and immobilizing enemies.
Boss fights are where Prey tests everything you've learned. This guide covers strategies for bosses across all areas, organized by progression order. For general combat techniques, see our combat guide.
Boss Difficulty Overview
| Area | Difficulty | Recommended Role | Key Weapons |
|---|---|---|---|
| Talos I Lobby | Easy | Typhon Psionics Build | Q-Beam |
| Psychotronics | Moderate | Typhon Psionics Build | Q-Beam |
| Arboretum | Hard | Human Only Build | GLOO Cannon |
| Deep Storage | Very Hard | Human Only Build | GLOO Cannon |
| GUTS | Extreme | Human Only Build | GLOO Cannon |
Talos I Lobby Bosses
Area difficulty: Easy Recommended level: Early Game (First Visit) Recommended role: Typhon Psionics Build with Q-Beam
Strategy
The first bosses teach core combat mechanics. Focus on learning patterns rather than dealing damage. Neuromods split into Human (Scientist, Engineer, Security) and Typhon (Energy, Morph, Telepathy) trees — this is your primary tool here.
Key tips:
- Don't rush. Learn the attack patterns first.
- Use Neuromod skill trees to create safe windows.
- Q-Beam is enough to handle everything here.
Psychotronics Bosses
Area difficulty: Moderate Recommended level: Early-Mid Game Recommended role: Typhon Psionics Build with Q-Beam
Strategy
Early game bosses test your understanding of GLOO Cannon physics. Players who skipped learning this mechanic will hit a wall here.
Key tips:
- GLOO Cannon physics is critical for these fights.
- Farm Q-Beam upgrades if you're struggling.
- Consider switching to Typhon Psionics Build if your current setup isn't working.
Arboretum Bosses
Area difficulty: Hard Recommended level: Mid Game Recommended role: Human Only Build with GLOO Cannon
Strategy
Mid-game bosses are the major skill check. They combine multiple mechanics and punish players who rely on a single strategy.
Key tips:
- You need both Neuromod skill trees and Typhon mimicry mastery.
- GLOO Cannon makes a significant difference — get it before attempting these.
- See our combat guide for advanced techniques.
Deep Storage Bosses
Area difficulty: Very Hard Recommended level: Mid-Late Game Recommended role: Human Only Build with GLOO Cannon
Strategy
Late-game bosses are serious challenges. Build optimization matters as much as mechanical skill.
Key tips:
- Make sure your build is fully optimized.
- GLOO Cannon at max upgrade is recommended.
- Study each boss's attack patterns — most have 2-3 phases.
GUTS Bosses
Area difficulty: Extreme Recommended level: Mid Game Recommended role: Human Only Build with GLOO Cannon
Strategy
Endgame bosses are the ultimate test. They require mastery of all combat systems and an optimized build.
Key tips:
- Top-tier build with best-in-slot gear is mandatory.
- Master every mechanic — see our combat guide.
- These fights reward patience and pattern recognition above all else.
General Boss Tips
- Learn before you fight — Spend your first attempt observing attack patterns. Don't try to win on attempt one.
- Match your build — Some bosses favor certain builds over others. Don't be afraid to switch.
- Upgrade your weapons — A max-upgraded GLOO Cannon trivializes fights that seem impossible with weaker gear.
- Use Neuromod skill trees — The core combat mechanic is your best defensive tool in every boss fight.
- Check the walkthrough — Our walkthrough tells you when you're ready for each boss.
More Prey Guides
- Prey Prey Overview
- Prey Best Builds
- Prey Tier List
- Prey Walkthrough
- Prey Beginner's Guide
- Prey Tips & Tricks
- Prey Weapons Guide
- Prey Combat Guide
- Prey Maps & Locations
- Prey Crafting Guide
- Prey Classes & Characters
Similar Games
If you enjoy Prey, check out these related guides:
- Counter-Strike 2 Boss Guide — fps game with similar mechanics
- Apex Legends Boss Guide — fps game with similar mechanics
- Rainbow Six Siege Boss Guide — fps game with similar mechanics
